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CD4 + T cells are the predominant lymphocytes infiltrating the exocrine glands in SS, and they persistently stimulate local immune responses, exacerbating inflammation and tissue destruction [86, 87]

Clofazimine is at least partially metabolised in the liver via CYP3A4 and CYP1A2, thereby TB smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments